Thursday, July 15, 2010

Summer Engineering Academy organized by OU College of Engineering


OM STAFF REPORTS
Oklahoman
Published: July 15, 2010

NORMAN — Forty-eight high school students and 11 teachers explored space this week from the University of Oklahoma campus, and it was free of charge.

OU: Katrina Hammonds puts data from an experiment into a computer as high school students participate in an engineering workshop at the University of Oklahoma's Devon Energy Hall in Norman. Photo by Steve Sisney, The Oklahoman

The Summer Engineering Academy, a National Science Foundation education program organized locally by the OU College of Engineering, was Monday through Wednesday, primarily in the various laboratories of the new Devon Energy Hall.

Students participated in workshops relating to aerospace engineering, solar energy and the greenhouse effect. The first part for teachers only was last week at OU. Teachers then applied their new methods for teaching science, math and engineering this week with the students.

Students gained hands-on learning experiences with the teachers' help in aerodynamics and flight controls, links between solar power and electrical engineering, and with atmospheric gases and the greenhouse effect in relation to environmental engineering.

They use what they learn in science and math classes to discover creative ways toward solving engineering and environmental problems.

The annual program's cost is free for both students and teachers, who had to apply to participate.

Wednesday, July 14, 2010

University of Oklahoma Researcher Developing Novel Therapy for Alzheimer's Disease

Contact: Jana Smith, Director of
Strategic Communications for R&D
University of Oklahoma
405-325-1322 or jana.smith@ou.edu

Norman, Okla.—A University of Oklahoma researcher is developing a novel therapy for Alzheimer’s disease using “biopharmaceutical proteases” to attack the toxic plaque that builds up in the brain of an Alzheimer’s patient—an approach that he predicts will be lower in cost and higher in effectiveness than current therapies.

Peter J. Heinzelman, an associate professor in the Department of Chemical, Biological and Mechanical Engineering, recently received a $75,000 grant from the Oklahoma Center for the Advancement of Science and Technology to pursue this research, which includes the development of a library of biopharmaceutical proteases for public use.

Heinzelman’s previous research led to the idea that proteases, or proteins that degrade other proteins, would be more effective as a therapy for Alzheimer’s disease than existing approaches. The brain is surrounded by a barrier of cells that allows glucose to pass through but is resistant to drug molecules and therapeutic proteins.

By virtue of a single protease molecule able to degrade thousands of the plaque molecules, these proteases should be capable of delivering a catalytic benefit even if only small amounts pass through the cell barrier surrounding the brain.

“Digestive enzymes are promiscuous,” says Heinzelman. “We can create catalytic proteases that attack the beta-amyloid plaque that cause neurons in the brain to die. Current therapies use amyloid-binding antibodies that are created by the body or injected to get rid of the plaque, but these antibodies used to attack the problematic Abeta molecules can only bind one time and clear one Abeta molecule, then they are done.”

The delivery system is problematic, too. Heinzelman suggests an approach that addresses both therapeutic efficacy and delivery. He wants to re-engineer an existing technology to link proteases with “ferrying” antibodies that can encourage passage of the proteases from the circulation side across the brain cell barrier and into the brain tissue. This approach has been demonstrated in the laboratory.

Another aspect of the OCAST grant is the development of a library of proteases that will be made freely available and could become a powerful tool for the scientific community. Heinzelman is working with researchers from the University of Wisconsin-Madison and the Oklahoma Medical Research Foundation on this grant.

For more information about Peter J. Heinzelman, his research interests and projects, visit his website at http://www.ou.edu/coe/cbme/audience/People/faculty1/heinzelman.html.